![]() In this "real world" study of changes in therapy in patients prescribed initial monotherapy with latanoprost with BAK or travoprost-Z with SofZia, medication changes were common in both treatment groups but statistically significantly more frequent with travoprost-Z. Among those who changed their index therapy, insufficient IOP control was the most commonly reported reason followed by adverse events hyperemia was the most commonly reported adverse event at index therapy change. Cohorts were similar with regard to age (median ~67 years), gender distribution (>50% female), and diagnosis (~80% with open-angle glaucoma). For both cohorts, average follow-up was >1 year. Resultsĭata from 900 medical charts (latanoprost, 632 travoprost-Z, 268) were included. Primary outcomes were rates of and reasons for changing from the initial therapy within six months and across the full study period (1000 days). Data regarding demographics, ocular/systemic medical histories, clinical variables, therapy initiations and reasons for changes, adverse events, and resource utilization were recorded from randomly chosen eligible charts. MethodsĪt 14 clinical practice sites, medical records were abstracted for patients with a diagnosis of open-angle glaucoma or ocular hypertension and who were ≥40 years of age, had a baseline and at least one follow-up visit, and had no prior history of ocular prostaglandin use. ![]() Because latanoprost and the original formulation of travoprost that included benzalkonium chloride (BAK) have been shown to be similar with regard to tolerability, we compared initial topical intraocular pressure (IOP)-lowering medication change rates in patients newly treated with latanoprost or travoprost-Z monotherapy. ![]()
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